Zhen Liang

Expression of SIX1 and TEAD1 in colorectal cancer and their synergistic effect on tumor growth via CTGF expression

The transcription factors SIX1 and TEAD1 are implicated in various malignancies, but their expression patterns and potential interplay in colorectal cancer (CRC) remain incompletely understood. Immunohistochemistry was performed to detect SIX1, TEAD1, and CTGF expression in CRC a...

Network analysis of frailty, sleep quality, and life satisfaction in older patients: a cross-sectional study stratified by chronic disease burden

Abstract Background Multimorbidity and chronic disease burden are common among older patients and are closely associated with frailty, poor sleep, and reduced subjective well-being. However, total-score-based analyses may obscure item-level interactions across health domains. Thi...