Zhen Ji

CD4+ cytotoxic T cells: context-dependent effectors in health and disease

Abstract Cytotoxic CD4 + T cells (CD4 + CTLs) have been identified as a specialized effector population characterized by potent cytotoxic machinery, including granzymes, perforin, and the Fas/FasL pathway, that enables the direct killing of MHC-II-expressing target cells. In addi...