Zhaonong Hu

Targeting Voltage-Gated Sodium Channels: Discovery of a Multi-Pest Insecticidal Activity Compound with Negative Cross-Resistance to Pyrethroid Resistance

Abstract The resistance to pyrethroid insecticides is becoming increasingly severe, while the number of insecticides with negative cross-resistance (NCR) remains extremely limited. Thus, the development of novel targets and candidate compounds is urgently required. To exploit NCR...

Biosynthesis and heterologous production of the α-agarofuran scaffold of Celangulin V from Celastrus angulatus

Celangulin V is a widely used biopesticide derived from Celastrus angulatus, and features antifeedant and insecticidal properties as a dihydro-β-agarofuran (DHβAF) sesquiterpenoid. Its biosynthesis remains largely unexplored. Here, we assemble a chromosome-level and haplotype-res...