Zhaojing Xu

Synthesis of Bioactive Fluorinated 2-Heterocyclic Pyrrolidines via Copper(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides

Abstract A copper-catalyzed asymmetric 1,3-dipolar cycloaddition of α-N-(heteroaryl-methyl)imines with gem-difluoroalkenes is reported. Using a Cu(I)/Segphos complex, this protocol provides diverse chiral fluorinated 2-heterocyclic pyrrolidines in high yields (up to 99%) with exc...