Zeru Li

Multidimensional 5-hydroxymethylcytosine features in cell-free DNA enable the detection, staging and subtyping of pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignant cancer with limited biomarkers for early detection and disease stratification. Here, we investigated whether multidimensional 5-hydroxymethylcytosine (5hmC) features in plasma cell-free DNA (cfDNA) could support...