Zeping Gui

Innate allorecognition induces HSP70 in monocytes contributing to renal allograft rejection

After encountering allogeneic nonself, monocytes differentiate to DCs, which in turn activate the adaptive immune system that drives transplant rejection. The downstream mechanisms of allorecognition are largely unknown. We analyzed scRNA-seq data sets to identify transcriptional...

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

ABSTRACT Renal allograft interstitial fibrosis/tubular atrophy (IF/TA) is the pathological hallmark of chronic renal allograft dysfunction (CAD) and endothelial‐to‐mesenchymal transition (EndMT) has been implicated as one of the key triggering factors. Here, we identified tumor n...