Zemfira N. Karamysheva

Active transcriptome remodeling underlies antimony-induced drug tolerance in persister-like Leishmania parasites

Persistence - characterized by the transient ability of subpopulations of Leishmania parasites to survive exposure to drugs - is a major driver of treatment failure and clinical relapses in leishmaniasis. Persisters are characterized by non-dividing or slow-growing state and incr...