Zekun Xu

PROTAC-Loaded Nanoparticles Induce a “ROS Storm” through Targeted Degradation of GPX4 in Combination with a Mild Photothermal/Fenton-like Reaction for the Treatment of Triple-Negative Breast Cancer

Abstract Proteolysis-targeting chimeras (PROTACs) are a promising therapeutic approach for degrading disease-causing proteins. However, they often encounter limitations in in vivo applications due to poor solubility, low cellular permeability, unfavorable pharmacokinetics, and mo...