Zefei Zhang

Preoperative renin-angiotensin system inhibitor management and acute kidney injury after cardiac surgery: a systematic review and meta-analysis

The optimal management of renin-angiotensin system inhibitors (RASIs) before cardiac surgery remains uncertain. Recommendations regarding continuation and preoperative temporary withholding and discontinuation differ, and the comparative effects of specific withdrawal timings on...

DMH glutamatergic and GABAergic neurons differentially regulate post-anesthesia sleep disturbance through CB1R signaling

Abstract Purpose Post-operative sleep disturbance affects more than 60% of surgical patients and impedes recovery. Although general anesthesia itself may profoundly remodel brain function and contribute to this pathology, the underlying neural mechanisms remain unclear. We previo...