Zefang Wang

Structural basis for loop-dependent inhibition by AcrIIC1 anti-CRISPR proteins

Most characterized anti-CRISPR proteins act via well-defined core inhibitory mechanisms, yet how auxiliary structural elements modulate and potentiate these canonical processes remains poorly understood. Here, we show that AcrIIC1Boe represses Nme1Cas9 activity through an integra...

An Extravasation-on-Chip Integrating Mechanical Measurements for Post-Extravasation Metastatic Pathways Study

Abstract Tumor cells (TCs) typically achieve brain metastasis through two distinct post-extravasation routes: invasion into the parenchyma or migration along the abluminal surface of vessels. However, the biomechanical cues dictating this route selection remain poorly understood....