Zane Jaunmuktane

Oligodendroglial somatic SNCA copy number gains are associated with inclusions and disease onset in multiple system atrophy

Abstract Multiple system atrophy (MSA) is a rapidly progressive synucleinopathy of unknown aetiology with neuronal and oligodendroglial α-synuclein inclusions. We previously reported somatic copy number variants (CNVs), specifically gains of SNCA (encoding α-synuclein) in MSA bra...