Zahi Touma

Antimalarial exposure and renal histopathologic findings in lupus nephritis

Abstract Objectives This study aimed to evaluate the association between antimalarial exposure and renal histopathologic findings at kidney biopsy in patients with lupus nephritis (LN). Methods This study was conducted within the University of Toronto Lupus Clinic cohort. To ensu...

Lupus Double-Negative B Cells Harbor Expanded Somatic Mutations in Lymphoma-Relevant Pathways

Objectives Systemic lupus erythematosus (SLE) patients have a 2–7-fold increased risk of hematologic malignancies, particularly B-cell non-Hodgkin lymphoma (B-NHL).[1] Although germline susceptibility shared between SLE and B-NHL is minimal,[2] somatic evolution of autoreactive B...