Zachary T. Medcalf

Thioamide‐Enabled Anodic N‐Centered Radical Cyclizations

An anodic cyclization leading to the 6‐membered ring, bisamine‐heterocyclic core of the chrysosporazine family of efflux inhibitors, has been accomplished. The reactions proceed through a N‐based radical intermediate that is derived from the oxidation of a thioamide anion and ben...