Yves Nominé

Pharmacological inhibition of UBASH3B induces mitotic arrest and selectively reduces tumor growth

Abstract Cancer cells tolerate mitotic errors to sustain proliferation, yet the molecular dependencies enabling this tolerance remain poorly understood and largely unexploited therapeutically. UBASH3B ensures mitotic fidelity by regulating Aurora B localization and is overexpress...

Distinct Molten‐Globule Conformations in an Interacting Protein Domain Resolved by 19 F NMR of Fluoroproline Residues

ABSTRACT Recently, the application of deep learning to structural data deposited in the Protein Data Bank has enabled the reliable and accurate prediction of 3D folded structures of proteins from their sequences. However, this approach is not applicable to highly dynamic proteins...

Distinct Molten‐Globule Conformations in an Interacting Protein Domain Resolved by 19 F NMR of Fluoroproline Residues

ABSTRACT Recently, the application of deep learning to structural data deposited in the Protein Data Bank has enabled the reliable and accurate prediction of 3D folded structures of proteins from their sequences. However, this approach is not applicable to highly dynamic proteins...