Yves Méchulam

EvolutionaryConvergence on a Dihydrofolate ReductaseMutation Drives Trimethoprim–Sulfamethoxazole Resistance in Burkholderia thailandensis

Abstract Trimethoprim–sulfamethoxazole (SXT) remains central to melioidosis eradication therapy, yet the genetic basis of resistance evolution in Burkholderia pseudomallei is not fully defined. Using Burkholderia thailandensis as a biosafe surrogate, we subjected populations to s...