Yuxuan Wang

HTR1D triggers osteosarcoma metastasis and doxorubicin resistance via c-MYC/MAPK feedback and CCL2/5-HT-mediated M2 polarization

Osteosarcoma (OS) treatment remains hindered by frequent metastasis and resistance to doxorubicin, the standard chemotherapeutic. Despite multimodal therapy, survival for advanced disease is dismal. Identifying molecular drivers that concurrently regulate invasion and chemoresist...

Vertical Heterogeneity of Deep Carboniferous Coal Reservoirs in the Northern Part of the Eastern Margin of the Ordos Basin

Deep coalbed methane (CBM) is an important frontier for expanding unconventional natural gas reserves and production in China. Significant vertical heterogeneity in coal reservoirs is a primary constraint on exploration and development, and the conventional interval subdivision b...

Foretinib triggers immunogenic cell death and enhances efficacy of anti-CD47 immunotherapy in colorectal cancer

Dual-target c-Met/VEGFR kinase inhibitors have emerged as promising therapeutic agents for cancer therapy, although their underlying antitumor mechanisms remain poorly defined. In this study, we demonstrate that foretinib, a selective c-Met/VEGFR2 inhibitor, triggers immunogenic...