Yuqing Cheng

Biologically reachable spectral fibres: repeat shuffling, copy ambiguity and the scarcity of cryptic pathogenic missense variants in ClinVar

A protein sequence encoder that depends only on k-mer statistics is blind to the rearrangements that preserve them: the spectral fibre of the protein. Most members of a fibre are not proteins that evolution or disease could produce. We ask which part of the fibre is biologically...

Biologically reachable spectral fibres: repeat shuffling, copy ambiguity and the scarcity of cryptic pathogenic missense variants in ClinVar

A protein sequence encoder that depends only on k-mer statistics is blind to the rearrangements that preserve them: the spectral fibre of the protein. Most members of a fibre are not proteins that evolution or disease could produce. We ask which part of the fibre is biologically...