Yulan Kui

Targeting NOX1/4 promotes macrophage phagocytosis and improves radiotherapy via YAP1/TEAD4-CD47 in non-small cell lung cancer

Abstract Radiotherapy is a mainstay treatment option for non-small cell lung cancer (NSCLC). However, radiation remodels the tumor immune microenvironment by adaptively upregulating the immunoregulatory checkpoint CD47, leading to phagocytic evasion and radioresistance. Although...