Yuki Nagashima

Targeting the Zinc Metalloproteinase Superfamily in the CNS: Medicinal Chemistry Strategies To Optimize Selectivity, Pharmacokinetics, and Blood–Brain Barrier Permeability

Abstract The zinc metalloproteinase superfamily [matrix metalloproteinases (MMPs), a disintegrin and metalloproteinases (ADAMs), and ADAMs with thrombospondin motifs (ADAMTSs)] represents a high-value yet elusive therapeutic target for peripheral disorders and central nervous sys...