Yuji Kamikubo

TREM2-LRP1 axis in Alzheimer's disease: pharmacological trade-offs of receptor shedding and functional restoration

Abstract The interplay between triggering receptor expressed on myeloid cells 2 (TREM2) and low-density lipoprotein receptor-related protein 1 (LRP1) is critical for amyloid-beta (Aβ) clearance in Alzheimer’s disease (AD). Current therapeutic strategies targeting this axis can be...