Yuhao Jiang

Engineering of Azo-Crosslinked Alginate Hydrogels for Targeted Oral Local Biologic Delivery

Abstract Oral delivery of therapeutic biologics is constrained by gastrointestinal degradation and premature leakage from physical hydrogels. Here, microfluidic-engineered azo-crosslinked alginate (SA-Azo) microspheres were fabricated via template-assisted covalent substitution,...

Design, Synthesis, and Evaluation of 99mTc-Labeled Proline Isonitrile Derivatives with Optimized Linker Lengths for Tumor SPECT Imaging

Abstract Amino acid metabolic imaging is among the important research directions in tumor molecular imaging. The highly active metabolism of proline in tumors, together with the abnormal expression of its key enzymes, makes it a promising target for tumor molecular imaging. To de...

Ultrasmall PolymericMicelles Enable Noninvasive TransdermalRosiglitazone Delivery via Lipid Fluidization and Transcytosis

Abstract Noninvasive transdermal drug delivery (TDD) offers sustained therapeutic release but is hindered by the stratum corneum (SC) barrier. Herein, we report ultrasmall polymeric micelles (PMs) embedded in poly(vinyl alcohol) hydrogels for the passive TDD of rosiglitazone (RGT...