Yuhan Chen

Targeting ADAR1 reprograms cold tumors to hot and enhances immunotherapy in bladder cancer

Despite significant advances in immunotherapy for certain solid tumors, bladder cancer (BCa) exhibits limited responsiveness, primarily due to its highly immunosuppressive “cold” tumor microenvironment (TME). The role of Adenosine Deaminase Acting on RNA1 (ADAR1) in regulating BC...

Icariin: Unraveling Ferroptosis Mechanisms, Metabolic Networks, and Innovative Therapy Strategies

Ferroptosis is an iron-dependent form of cell death driven by lipid peroxidation. This concept reshapes our understanding of tissue degenerative lesions and oncogenesis. Icariin (ICA) is an isoprenyl flavonol glycoside derived from plants of the genus Epimedium. Acting as a bidir...