Yueyue Huang

Single-blastomere next-generation sequencing confirms chromosomal abnormalities as the primary cause of impaired developmental potential in embryos with abnormal cleavage patterns

Abnormal cleavage impairs embryonic development, but the effects of different abnormal cleavage patterns and occurrence stages remain unclear. Previous chromosomal analyses at the blastocyst stage have failed to elucidate the underlying mechanism. This study investigated the effe...

A Metabo‐Reprogramming Niche Remodeling System Halts Osteoarthritis by Restoring the FGF21‐Arginine Axis

Osteoarthritis (OA), a global leading cause of chronic pain and disability, lacks disease-modifying osteoarthritis drugs (DMOADs) targeting its core pathogenesis. scRNA-seq of human OA cartilage showed marked depletion of a high-arginine-metabolism chondrocyte subpopulation drivi...