Yuchao Qiao

Multi-Endpoint Prediction of Bioactivity and ADMET Properties Coupled with Multi-Objective Optimization in Molecular Descriptor Space for Candidate ERα Antagonists

Objectives: Candidate estrogen receptor alpha (ERα) antagonists should combine strong inhibitory activity with favorable absorption, distribution, metabolism, excretion, and toxicity (ADMET)-related properties. This study developed an integrated framework for multi-endpoint predi...