Yuanyuan Zhao

Multi-omics analysis identifies the super-enhancer-driven gene NPW in left-sided obstructive lesions-associated cardiac remodeling

Left-sided obstructive lesions (LSOLs), represented by coarctation of the aorta (CoA), cause persistent vascular pathology and pressure overload that can lead to pathological cardiac remodeling. However, the epigenetic changes associated with local vascular abnormalities and vent...