Yuanyu Zhang

Age-related degeneration initiates at the surface: preferential biomechanical and biological decline in rat articular cartilage

Age-related degeneration of articular cartilage is a key pathological hallmark of primary osteoarthritis (OA). As the cartilage’s barrier layer, the superficial zone maintains tissue homeostasis and is increasingly recognized as the initial site of age-related cartilage degenerat...