Author
Yuanyong Huang
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Recent research
- BiologyOpen access
Mammalian DNA maintenance methylation depends on histone but not PAF15 ubiquitination
In mammals, DNA methylation is an essential inheritable epigenetic modification maintained by the DNMT1-UHRF1 machinery in a UHRF1 E3 ubiquitin ligase-activity-dependent manner. UHRF1-catalyzed histone ubiquitination and PAF15 ubiquitination have been proposed to recruit DNMT1 to...