Yuan-Tong He

mRNA-LNP vaccines targeting conserved virulence factors elicit protective immunity against lethal Legionella pneumophila infection

Legionnaires’ disease (LD), caused by the intracellular pathogen Legionella pneumophila , imposes a substantial global health burden, yet no vaccine has been clinically approved. Here, we develop mRNA-LNP vaccines encoding conserved virulence factors Pal, PilE, and FlaA. In BALB/...