Yu Nishio

Drug‐Derived Tetrahydropyrazines for Late‐Stage α ‐ and β ‐Functionalization of Piperazine‐Based Pharmaceuticals

ABSTRACT Piperazine is one of the most prevalent saturated nitrogen heterocycles in pharmaceuticals, yet late‐stage access to α ‐ and β ‐substituted piperazine analogues remains challenging. Here, we report a flavin‐photocatalyzed platform that converts complex piperazine‐contain...