Yu Hu

Kidney fibrosis is mediated by GARP-restricted TGF-β activation in fibroblasts

TGF-β is a central driver of kidney fibrosis, a common pathological hallmark of chronic kidney disease (CKD). Initiation of TGF-β signaling requires not only its synthesis but also the conversion of latent TGF-β to its bioactive form. However, the mechanisms governing TGF-β activ...