Yu Guo

Pd-Catalyzed Freon-Enabled Aminocarbonylation of Aryl Iodides

Abstract A palladium-catalyzed Freon-to-carbonyl transfer strategy has been developed for the CO-free aminocarbonylation of aryl and heteroaryl iodides with amines. Using chlorodifluoromethane (Freon-22) as both a difluorocarbene precursor and a carbonyl source, this protocol ena...