Yu Guo

SLC7A11-associated astrocyte states are linked to redox imbalance and synaptic microenvironment remodeling in multiple sclerosis: translational implications

Abstract Background Multiple sclerosis (MS) is characterized by inflammatory demyelination, oxidative stress, and neurological dysfunction. Despite disease-modifying therapies, chronic active lesions and ongoing neurodegeneration remain largely untreated, highlighting the need fo...

Rapamycin‐nanoliposomes target the mTORC1 ‐mediated autophagy–lysosomal and NLRP3 /Caspase‐1 pathways to inhibit nucleus pulposus cell senescence in intervertebral discs

Abstract Nucleus pulposus (NP) cell quiescence maintains intervertebral disc homeostasis, while mTORC1 regulates autophagy–lysosomal function and inflammatory secretion to preserve quiescence—rapamycin specifically targets mTORC1. Herein, we fabricated rapamycin‐nanoliposomes (ra...