Yu Chen

Cell-inspired dual-tandem catalytic nanoreactors drive targeted hearing protection

Sensorineural hearing loss is driven by disruption of cochlear homeostasis, where dysregulated redox, ionic, and metabolic factors lead to hair cell degeneration and synaptic injury. Current strategies lack the capacity to restore the enzymatic clearance of reactive oxygen specie...

Cantharidin Causes Hepatotoxicity by Disrupting GSH‐Mediated Redox Homeostasis

ABSTRACT Cantharidin (CTD) possesses potent anticancer activity, whereas its prominent hepatotoxicity severely limits its clinical application. Because the detailed molecular mechanisms responsible for CTD‐triggered hepatotoxicity have not been fully elucidated, additional invest...

Development of a treatment classification system and treatment strategy for ligamentous ossification disease-traditional and innovative surgical strategies

Ligamentous ossification diseases like OPLL and OLF can cause severe neurological compromise. While whole-spine CT identifies ossified segments and MRI reveals cord compression/signal changes, treatment guidelines—especially for multi-level involvement—remain undefined, particula...