Yousong Ding

KRstereo: Predicting β-Hydroxy Stereochemistry in Polyketides Using Protein Language Models

Abstract Polyketides are a major class of bioactive natural products whose activities are often determined by the stereochemistry of β-hydroxyl groups. In type I polyketide synthases (PKSs), ketoreductase (KR) domains establish these stereocenters, making accurate prediction of K...

Characterizationof Dapalides D and E and GenomicComparison of the Two Co-Occurring Dapalide-Producing Dapis spp.

Abstract Marine cyanobacteria are a rich source of diverse bioactive natural products, targeting proteins involved in many diseases. Here, we combined metagenomic analysis to enhance the structure elucidation process of two new cyclodepsipeptides named dapalides D (1) and E (2) f...