Yousaf Khan

Design, synthesis, and biological evaluation of pyrimidine linked fused thiazole–isoxazole conjugates as dual cholinesterase inhibitors for Alzheimer’s disease

Abstract Alzheimer’s disease (AD) affects over 55 million individuals worldwide, yet approved pharmacotherapies remain limited to symptomatic relief. Dual inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) offers a validated approach to restoring choliner...

Multitargeted drug strategies for Alzheimer’s and Parkinson’s diseases

Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are multifactorial diseases that are characterized by several interconnected pathological mechanisms, such as the aggregation of amyloid-beta (Aβ), hyperphosphorylation of tau, accumulati...