Yoshimitsu Katayama

Adaptive Neurovascular Assembly: Probability-Enriched Module Selection and Permissive Scaffold Guidance without Forced Connection

Exact mechanical docking can reduce geometric error, but it cannot guarantee endothelial continuity, stable perfusion, axonal crossing, myelination, synaptic integration, or safe electrical function. Excessive fixation may instead create compression, inflammation, thrombosis, mis...

Autonomous Vascular Homeostasis: A Physical-AI Framework for Maturation, Self-Maintenance, and Thresholded Rescue

Successful vascular formation is not equivalent to mature autonomous function. Engineered vessels may remain dependent on continuous growth factors, external flow schedules, or active rescue. This Version 3 proposal defines autonomous vascular homeostasis as the capacity of a mat...

Dual-Field Vascular Guidance: A Physical-AI Framework for Spatially Coupled Demand and Stabilization Microenvironments

This proposal translates the conceptual distinction between a “rescue-demand field” and a “developed-support field” into measurable vascular microenvironments. A spatially separated demand field supplies calibrated angiogenic and injury-like cues that initiate vascular exploratio...

Autonomous Vascular Homeostasis: A Physical-AI Framework for Maturation, Self-Maintenance, and Thresholded Rescue

Successful vascular formation is not equivalent to mature autonomous function. Engineered vessels may remain dependent on continuous growth factors, external flow schedules, or active rescue. This Version 3 proposal defines autonomous vascular homeostasis as the capacity of a mat...

Adaptive Closed-Loop Vascular Navigation: A Physical-AI Framework for State-Responsive Angiogenic Guidance and Self-Extinguishing Demand Fields

Static scaffolds and fixed growth-factor gradients provide an initial instruction but cannot respond when a vascular sprout deviates, connects, leaks, regresses, or completes perfusion. This Version 2 proposal introduces state-responsive vascular navigation. A physical-AI control...

Adaptive Neurovascular Assembly: Probability-Enriched Module Selection and Permissive Scaffold Guidance without Forced Connection

Exact mechanical docking can reduce geometric error, but it cannot guarantee endothelial continuity, stable perfusion, axonal crossing, myelination, synaptic integration, or safe electrical function. Excessive fixation may instead create compression, inflammation, thrombosis, mis...