Yoshihiro Shimada

DDI-4 induces a temperature-sensitive exocytotic remodeling during C. elegans spermiogenesis via nsun-2–dependent sphingosine signaling

Exocytotic sperm remodeling is essential for fertilization, yet whether conserved molecular mechanisms underlie this process across species remains unclear. In Caenorhabditis elegans , membranous organelle fusion (MOF), an exocytotic event cytologically analogous to the mammalian...