Yoshihiro Komohara

Establishment and Characterization of OK-ATC1 and OK-ATC1-PDX: a Novel Cell Line and Patient-Derived Xenograft Model of BRAF V600E-Mutated Anaplastic Thyroid Carcinoma

Abstract Anaplastic thyroid carcinoma (ATC) is characterized by rapid progression, marked biological heterogeneity, and rarity, which makes clinical studies difficult to conduct. The development of novel therapeutic strategies for ATC thus requires appropriate experimental animal...

Shared cancer resistance but divergent immune responses in two long-lived African mole-rat species: the naked mole-rat and the Damaraland mole-rat

Several exceptionally long-lived mammals show natural resistance to cancer. The longest-lived rodent, the naked mole-rat (NMR; Heterocephalus glaber ) is renowned for its remarkable resistance to carcinogenesis; however, it is unclear whether other long-lived African mole-rat spe...

Prior vedolizumab exposure and fibroblast-derived MMP13 are associated with ustekinumab nonresponse in ulcerative colitis

Abstract Background As therapeutic options for ulcerative colitis increase, optimizing the sequencing of advanced therapies has become an important challenge. We examined whether baseline clinical characteristics influence the effectiveness of ustekinumab and investigated molecul...

Aberrant SOX9 expression mediated by protumour macrophages predicts poorer clinical outcomes in hepatoblastoma

Tumour-associated macrophages (TAMs) are known to promote tumour progression in many kinds of malignant tumour, including hepatoblastoma (HB). Based on previous studies, we suggested that TAM-mediated sex-determining region Y-box 9 (SOX9) signal might enhance HB progression. The...