Yoshifumi Shimada

Allele-specific directionality and evolutionary timing of BRCA1/2 loss of heterozygosity in gastric cancer

Abstract Germline pathogenic variants in BRCA1 and BRCA2 are established cancer predisposition factors, but their biological role in gastric cancer remains poorly defined. We investigated whether BRCA1/2 -associated gastric cancers acquire loss of heterozygosity, which allele is...