Yongzhao Bi

Interaction ofFood-Derived Bitter Peptides with hTAS2R4:Recognition and Activation Mechanisms Revealed by Docking and Mutagenesis

Abstract Bitter peptides (BPs) have a wide range of applications in the food and pharmaceutical industries. This study identified four food-derived BPs (TPLVDR, VLY, LEEL, and FYL) as novel agonists of the human bitter taste receptor hTAS2R4, using a rapid cell-based screening ap...