Yongjin Zhang

Multi-omics and single-cell analysis link the pan-cancer TOP2A-immune exclusion paradox to a non-cell-autonomous dilution effect

Abstract Background TOP2A is universally upregulated in human cancers, yet its negative correlation with immune infiltration in bulk transcriptomes remains mechanistically unresolved at single-cell resolution. Methods We integrated multi-omics data across 34 cancer types with ext...