Yongjie Xie

Single-Cell and Spatial Transcriptomics Reveal CHCHD3 as a Therapeutic Target to Activate cGAS-STING and Overcome Immunosuppression in Lung Adenocarcinoma

Abstract A substantial proportion of treatment-naive lung adenocarcinoma (LUAD) patients exhibit intrinsic resistance to neoadjuvant chemoimmunotherapy, highlighting the need for mechanism-driven therapeutic strategies. Here, we performed integrated single-cell RNA sequencing (sc...