Yong Zhao

Phosphorothioate-Enabled Cas12a Autocatalytic Networkfor Amplification-Free Ultrasensitive Nucleic Acid Detection

Abstract Autocatalytic CRISPR/Cas systems offer a promising route toward amplification-free nucleic acid detection, yet their performance is limited by indiscriminate transcleavage of ssDNA activators and the reliance on structurally complex, thermodynamically unstable DNA archit...

Full-Range Ultrasensitive Fiber-Optic Hydrogen Detection via Twin Vernier Amplification and Lightweight CNN

Reliable hydrogen monitoring requires sensors that combine high sensitivity, wide dynamic range, and resistance to environmental interference. Here, we report a monolithically integrated dual-Fabry-Pérot interferometer (dual-FPI) fiber-optic hydrogen sensor that couples twin Vern...