Yixi Wang

Immune response to DNA and RNA: structural insights, molecular mechanisms, and therapeutic targeting

Abstract The recognition of mislocalized DNA and RNA by cGAS–STING, RIG-I/MDA5, the OAS–RNase L axis, and endosomal TLR3/7/8 has emerged as a unifying paradigm linking cancer, autoinflammation, and antiviral immunity. Counterbalancing these sensors is a structurally heterogeneous...