Yinyin Zhuang

Lipid-driven membrane remodeling engages a lysosome-dependent adaptive repair program during retinal aging

Abstract Age-associated remodeling of membrane lipid composition has been implicated in cellular dysfunction, yet the mechanisms linking lipid changes to membrane integrity and disease remain poorly defined. In the retinal pigment epithelium (RPE), lipid dysregulation is strongly...

Reconstitution of lamin assembly on nuclear pore complex-containing membranes

Intermediate filaments called lamins line the metazoan nuclear envelope and organize the nucleus and genome. Unlike actin and microtubules, purified intermediate filament proteins assemble into non-physiological structures, making it difficult to connect lamin functions to their...