Ying Zhao

A metabolite-pair controlled quiescence switch via ATP-dependent phase separation

Abstract Amino acid oxidation during carbon starvation inevitably generates NH₄⁺ and HCO₃⁻ as byproducts. Here we show that this metabolite pair acts synergistically to deplete cellular ATP, a task neither accomplishes alone. Rather than nutrient starvation itself, it is this spe...