Ying Yang

STAT3/NF-κB signaling axis in macrophage and myeloid-derived suppressor cell driven immune evasion in lung cancer

Immune checkpoint blockade (ICB) has brought transformative advances to lung cancer management; nevertheless, immunosuppressive tumor microenvironment (TME)-mediated therapeutic resistance constitutes a prominent unsolved bottleneck, mainly originating from the sustained buildup...

Asymmetric RBBP7 regulates the first cell fate decision of early mammalian embryos

Asymmetric transcription of noncoding RNA LincGET is currently recognized as the earliest event regulating the first cell fate decision in mammalian embryogenesis. However, whether key protein factors modulate this process remains elusive. Here, we identify RBBP7 as the earliest...