Ying Fu

TsCl-Mediated, Copper-Catalyzed Deoxygenative Difluoromethoxylation Reaction of Quinoline- N -Oxides

Abstract Quinoline derivatives have played a pivotal role in the design and synthesis of drug-active substances and bioactive molecules for a long time. Herein, a TsCl-mediated, copper-catalyzed deoxygenative difluoromethoxylation reaction that facilitates the synthesis of 2-difl...

Copper/Iron-CocatalyzedSynthesis of FunctionalizedQuinazolines from gem -Difluoroalkenes and Amidines

Abstract A novel and efficient method for synthesizing functionalized acyl quinazolines has been developed via CuCl2·2H2O/FeBr3-cocatalyzed cascade cyclization of amidines with readily accessible gem-difluoroalkenes. The reaction proceeds in DMF under an air atmosphere, affording...