Yinfeng Yuan

Excitatory neuronal TIA1 in ventral hippocampal CA1 drives antidepressant-like effects via downregulation of Cacna2d1 signaling in mice

Stress is a known risk factor of major depressive disorder (MDD). T cell-restricted intracellular antigen 1 (TIA1) is an RNA-binding protein that regulates mRNA stability and translational repression. However, its roles in MDD remain largely unknown. Here, we found that TIA1 was...