Yiming Deng

HLA-DMA depletion suppresses malignant glioma phenotypes and murine H2-DMa knockdown enhances the response to anti-PD-1 therapy

Glioblastoma (GBM) exhibits poor responsiveness to immune checkpoint blockade, largely due to an immunosuppressive tumor immune microenvironment. Tumor-associated macrophage (TAM) polarization critically regulates antitumor immunity, yet the role of human leukocyte antigen class...